The Kuumba Singers of Harvard College celebrate the African-American aural tradition, and have done so for almost 40 years. The singers held their annual winter concerts, a holiday tradition of songs and dances, in Memorial Hall in early December.The group’s Web site says its name was chosen because it “allowed for all modes of diasporic expression. In Swahili, ‘kuumba’ roughly means creativity, though the literal meaning is more subtle: It is the creativity of leaving a space better than you found it.”Kuumba singer Amber James ’11 added, “The songs we sing and the dances we do and the poems we read, they are all designed to bring people together in celebration of black creativity and spirituality. The concert is so moving because of the range of emotions that are represented in music from the black diaspora. Pain, sorrow, strength, resilience, peace, joy, love, and countless others are all intensely felt through the music and movements.” Singing from the heart Impassioned vocalists Omobolaji Ogunsola ’10 (from left), Amber James ’11, Kaydene Grinnell ’10, and Marissa Glynias ’12 give it all they’ve got. A chorus line Matthews Mmopi ’11 (from left, red shirt), Nathan Whitfield ’09, Omobolaji Ogunsola ’10, Amber James ’11, Kaydene Grinnell ’10, and Marissa Glynias ’12 rehearse for the Kuumba Winter Concert. Dancer in red A singing and swaying Amber James ’11 at rehearsal for the Kuumba Winter Concert inside the Memorial Church. Harvard Kuumba Singers Dressed to sing Darkly and festively draped, the Kuumba Singers unite. Flight of the Kuumba Singers This regal-looking statue overhears Maxwell Nwaru ’10 rehearsing. Full house Under the Memorial Church’s white pillars, a rapt audience watches as the Kuumba Singers process to the stage. Kris Snibbe/Harvard Staff Photographer
Transforming cancer treatment A fuller picture of cancer New plan of attack in cancer fight Three-dimensional model of solid tumors explains cancer evolution Discoveries in cancer research have included everything from genes that can transform healthy cells into tumor cells to advances related to tumor immunology, but those breakthroughs have often led to new complexities, leaving researchers with additional questions.Now, the limits of those complexities may be coming into view.Evidence uncovered by a team of researchers that included Martin Nowak, a professor of mathematics and of biology, suggests that, within individual patients, the majority of driver mutations — genetic mutations that help create or sustain cancerous cells — are shared by both the primary tumor and metastases. The study was described in a paper published last month in Science.That finding is critical because it creates hope for targeted combination therapy against metastatic cancer, said Nowak, also the director of the Program for Evolutionary Dynamics. Rather than trying to combat the effects of dozens of different genes, clinicians might only have to design treatments for a handful of cancer drivers for an individual patient, he said.“Whenever cells divide in the body, mutations occur,” Nowak said. “Most of those mutations don’t cause problems, but some mutations are steps toward cancer. We call them drivers. If we want to use precision medicine against the disease, we need to know what those driver mutations are.“One outcome of our study could have been that we found different driver mutations in different metastases,” he continued. “That would have been a real problem, because the hope is that, in a few decades from now, precision medicine will allow a doctor to identify those driver mutations in a patient and then target them using specific treatments. But if they were different for every metastasis, that would be impossible.”Though personalized cancer therapies are still years away, the study offers an important signal that they might one day be reality, Nowak said.“The finding gives us hope that such treatment is possible. Because if metastases share the same driver mutations, then if we target those mutations, it may be possible to control metastatic disease.” Related Researchers demonstrate that a two-drug combination, under certain circumstances, can eliminate disease Multidrug strategy emerges from new research A shared set of driver genes, Nowak added, would also make diagnosis far easier. Rather than having to identify specific mutations in every metastases of a patient, doctors would need to perform just a single biopsy of the primary tumor.To begin to understand which mutations are found in metastases, the researchers — including Johannes Reiter of Stanford University, Bert Vogelstein of Johns Hopkins University, and Christine Iacobuzio-Donahue of the Memorial Sloan Kettering Cancer Center — had to obtain samples from metastatic cancer patients before they were treated for the disease.“Most cancer studies analyze the primary tumor,” Reiter said. “There are not many cases where we have genetic information from the primary tumor and several metastases and moreover in patients that have not been treated with chemotherapy. Such treatment could induce many additional mutations.”The team found 20 patients who matched the criteria, Reiter said, and analyzed genetic sequencing data from 76 metastases in those patients. The cancers were breast, colorectal, endometrial, gastric, lung, melanoma, pancreatic, and prostate.Nowak cautioned that researchers still face challenges in designing drugs to target driver mutations and in overcoming challenges related to drug resistance in cancer cells.“There are many challenges that remain,” Nowak said. “But in some sense now, hope is possible. There is hope because it appears there is a limit to cancer’s complexity … for the first time we see a light at the end of the tunnel.”This research was supported by funding from the National Institutes of Health, the Lustgarten Foundation for Pancreatic Cancer Research, the Sol Goldman Pancreatic Cancer Research Center, the Virginia and D. K. Ludwig Fund for Cancer Research, an Erwin Schrödinger Fellowship, a Landry Cancer Biology Fellowship, and the Office of Naval Research.
We’re living through a time of rapid transformation—where technology that helps us connect, collaborate and communicate has taken center stage. We’ve been talking about this period as the “Renaissance of the PC”, where we have a unique opportunity to think and do differently to drive better customer experiences. This “renaissance” doesn’t only apply to the device itself, but how the broader computing ecosystem can come together to drive modern experiences.Today we’re doing just that with the Modern Computing Alliance. We’ve joined as a proud founding member, alongside Google, Intel, VMware, Citrix and many other members.What is our goal with the Modern Computing Alliance? It’s simple: to drive an open and innovative ecosystem so customers can get the most from their Chrome OS experiences.Take our Latitude Chromebooks as an example. We already give IT departments the flexibility to easily integrate the Chrome OS into their ecosystem while still enjoying the global availability, scale and features that our Latitude devices offer.The Modern Computing Alliance will further build on this idea.We will collaborate with everyone from software partners to Silicon Valley start-ups to drive more value and innovation for Chrome OS in the broader IT ecosystem. Looking beyond devices, we’ll explore things like data security, insights and multi-factor authentication to create more value and innovation for people like you and me. People that use our devices every day.If there’s anything I’ve learned this year, it’s that our diverse viewpoints and collective strengths can bring about amazing changes – a “renaissance” – for customers and for ourselves. Our goal for our work with the Alliance is that we bring even more innovative, flexible experiences to you. Learn more here.
Tags: flooding, holy cross drive, power outage, saint mary’s drive After historic rainfall hit South Bend late Monday night, Notre Dame faced a power outage to about ten percent of campus, according to the University Twitter account. Power was restored to all of campus of 4:30 p.m., according to a Facebook post from the University, after personnel in the utilities department and the risk management and safety department pumped out flooded electrical vaults and dried electrical systems throughout buildings across campus.Additionally, the University was able to reopen Holy Cross Drive, by the Grotto, which they had closed earlier that day, according to the post. “Until the standing water on Saint Mary’s Drive subsides, it will remain closed. Notre Dame Security Police will closely monitor and open as soon as the road is safe,” the post said. The University closed several campus buildings Tuesday, including Fitzpatrick Hall, Moreau Hall and Ave Maria Press, but campus safety expected to clear all of the buildings to reopen Wednesday morning, according to tweets from the University.
Sugar, butter and flour for everyone! The new Broadway musical Waitress, directed by Tony winner Diane Paulus and featuring a score by Grammy nominee Sara Bareilles, will launch a national tour next year. The tour will kick off at Cleveland’s Playhouse Square on October 17, 2017. Casting and further engagements will be announced at a later date.The show made history as the first Broadway musical to feature an all-female creative team; in addition to Bareilles and Paulus, on board are book writer Jessie Nelson and choreographer Lorin Latarro.Based on the 2007 film by the late Adrienne Shelly, Waitress follows Jenna, a small town waitress stuck in a loveless marriage. As a nearby baking contest approaches (and a new doctor comes to town), she’s torn between her commitments and—thanks to her pie-making expertise—a chance at freedom.The Broadway production opened officially at the Brooks Atkinson Theatre on April 24. The current cast features Tony winner Jessie Mueller as Jenna, Drew Gehling as Dr. Pomatter, Kimiko Glenn as Dawn, Keala Settle as Becky, Nick Cordero as Earl, Christopher Fitzgerald as Ogie, Dakin Matthews as Joe and Eric Anderson as Carl. Keala Settle, Jessie Mueller & Kimiko Glenn in ‘Waitress'(Photo: Joan Marcus) Related Shows Waitress Sara Bareilles View Comments Star Files Show Closed This production ended its run on Jan. 5, 2020
Sign up for our COVID-19 newsletter to stay up-to-date on the latest coronavirus news throughout New York Crews are working on the new Long Beach boardwalk, which will have new features that should make it more durable during future storms. (Rashed Mian/Long Island Press)Michael Creaney was taking his daily bicycle ride through Long Beach when he cut a left near what used to be the seaside city’s iconic oceanfront boardwalk and pressed hard on the breaks, skidding to a stop.The 58-year-old Long Beach native, who biked on the boardwalk for as long as he can remember, hopped off along Riverside Boulevard where crews were constructing a redesigned boardwalk after the previous one, built in 1907, was destroyed by Superstorm Sandy’s unrelenting storm surge seven months ago.“I thanked these gentleman for rebuilding my boardwalk,” Creaney said, the buzzing of construction tools cutting through the air on an eerily quiet Thursday afternoon as crews bulldozed through areas where locals once gathered before spilling onto the beach.The 2.2-mile-long wooden structure was completely demolished three months after Sandy and reconstruction efforts began four months after that. Crews are about two months into the rebuilding effort.The city has made attempts to highlight the progression of its rebuilding efforts—first in January to memorialize the century-old boardwalk followed by an April pep rally to celebrate the first day of construction for the new wood structure rising from the sand. Both events attracted hundreds of locals, many lamenting the loss of their beloved boardwalk.On April 4, the city agreed to a $44.2 million contract with Plainview-based Grace Industries, LLC to takeover the rebuilding effort. About 90 percent of the cost is to be paid for by federal funding, according to city officials. The remaining 10 percent is to be split roughly 50/50 between New York State and the city.Long Beach’s agreement with Grace Industries stipulates that the project be completed within 210 days from the day that the first shovel hit the ground, and a $15,000 penalty for each day the company goes over that benchmark was included in the deal in an attempt to squash any thought of a delay. That would put the boardwalks grand opening sometime in November, but officials said the public will be allowed to access a half-mile stretch of the new boardwalk in July for bicycling, walking, and perusing the new structure.But, only two months into the rebuilding effort, some residents are already questioning why the boardwalk hasn’t risen in time for the summer.“Does anyone else think it’s annoying how the Jersey Shore is rebuilt but their just starting the boardwalk in Long Beach,” vented one Twitter user.One resident at the June 4 city council meeting simply asked: “When is it going to open?”City officials are asking for patience. A common refrain from Long Beach is the new boardwalk is being built “stronger, smarter and safer.”But residents can’t help but compare the City by the Sea’s rebuilding effort to that of the Jersey Shore, which opened for business in time for Memorial Day. And, specifically, the 1.3-mile long boardwalk in Belmar, New Jersey, which cost $8 million and has already been completely rebuilt.“I understand their concern but what the residents should know is that we surveyed the residents in Long Beach and 88 percent of the residents that we surveyed voted for a stronger and safer boardwalk and that’s what we’re doing,” City Councilwoman Eileen Goggin said in an interview along the construction site.The iconic Long Beach boardwalk was demolished after it was crushed by Superstorm Sandy. Now crews are working to reconstruct a redesigned boardwalk that will open in November. (Rashed Mian/Long Island Press)“We’re not just patching up the boardwalk that we had,” she added. “We’re using tropical wood, cement, which is what the residents voted for, so it’s a process. We’re building a boardwalk now that will last hopefully a hundred years. A stronger, safer boardwalk, and so it takes time.”Mark Tannenbaum, executive vice president of the Long Beach Chamber of Commerce, understands why some residents have voiced concern about the project, but endorsed a new and improved boardwalk, which will be better for the city in the long run, rather than putting one together for the summer with “spit and gum,” he said.“It won’t come down again,” Tannenbaum said of the redesigned boardwalk. “And if it does come down it will be at FEMA’s (Federal Emergency Management Agency) penny.”The new boardwalk could also bring more opportunities for local businesses because residents have shown support for opening shops on the boardwalk, he said.But city officials are focusing on their current challenges. The city has been touting the boardwalk’s durability under the new project, which includes mitigation designs to build a boardwalk that can withstand future storms. A concrete retaining wall on the south side of the boardwalk should serve as a barrier next time Mother Nature decides to unleash a storm similar to Sandy on LI.“Waves will not be able to get through like the last storm and cause the destruction that [it] did,” Goggin said.A new tropical hardwood decking, similar to those installed throughout the state and in New Jersey, will also help alleviate the problem of non-stop maintenance that occurred at the previous boardwalk, officials said.The biggest change on the boardwalk itself, however, is a wood and concrete stretch from National Boulevard to Long Beach Road in the middle of the boardwalk where officials anticipate the heaviest amount of traffic will come from. Old fashioned lights will also sprout up along the boardwalk to create a “beautiful nostalgic feeling,” Goggin said.“It’s unfortunate that it will be November,” she added, “but at the same time we’re building something that is going to last a long time so we can’t rush it.”Creaney, the bicyclist, said he’s willing to wait, so long as the boardwalk is built as advertised.“I wish it was there today,” he said, “but I want them to do it right and do it properly.”
The countries involved with ETS include Belgium, the Netherlands, Denmark and SwedenShe added that the ETS is now also exploring how national tracking services can be connected.As a follow-up to last year’s questionnaire about an overview of the various pensions communication methods across the EU, the ETS has recently launched an online survey to analyse internal communication processes, countries’ objective of informing citizens as well as the content and presentation of information.The ETS said the results will be shared during an online event at the end of June.… to wider roll-outAccording to Wegner-Wahnschaffe, the next three to five-year phase of the project is to comprise the roll-out of the information platform to the 12 EU member states that already have a national tracking service in place.She added that Germany, Luxembourg, Croatia, the Czech Republic as well as the UK have started developing a local tracking service.Wegner-Wahnschaffe added that, following the UK’s departure from the EU, it is unlikely that the country will feed data into the European tracking system.However, data in the ETS will remain available to UK users if the UK uses a compatible authentication tool, she said.The European pensions tracking system is ultimately to provide three layers of information, including individual pensions information, a pensions summary as well as projections of future pension income.The ETS project leader declined to predict when the ETS could be completed across the entire EU, citing “too many uncertainties”.FundingWegner-Wahnschaffe noted that, for example, the European Commission hadn’t yet committed funding for the roll-out phase of the project.However, she said she was confident that funding would be provided, since the European pension tracking service was “still high on the priority list of both the EC and many member states”.Last year, Wegner-Wahnschaffe estimated that a fully functioning ETS covering the entire EU could take up to 12 years to achieve.She now argued that the ETS could also be considered as complete when it covers a “sufficient share” of the mobile workforce.The ETS project is supported by a consortium of eight large European stakeholders sharing expertise.They include the Belgian social security databank Sigedis, Dutch pension providers APG and PGGM, the Swedish Pensions Agency and the German public pensions provider Versorgungsanstalt des Bundes und der Länder (VBL) as well as European industry organisation AEIP, the Swedish tracking service Minpension.se and the Belgian Federal Pension Service (FPS).Looking for IPE’s latest magazine? Read the digital edition here. Mobile workers in the EU should be able to find their pension providers in at least five member states on a European pension tracking platform by the end of 2021, according to the project leader for the European Pension Tracking Service (ETS).According to Claudia Wegner-Wahnschaffe, the countries involved include Belgium, the Netherlands, Denmark and Sweden, and possibly also Germany and Italy.The ETS project is aimed at developing a pilot, including a website – Find Your Pension (FYP) – for a European cross-border pension tracking service.This must enable mobile workers – estimated at 4.2% of the employee population – to find their pension providers, and provide them with an overview of their pension claims in different countries and systems. From ‘proof of concept’ …Wegner-Wahnschaffe said that a “proof of concept” for an effective and secure way of data exchange had been developed with the Belgian project partners.“Belgium already uses the eIDAS authentication framework, which the ETS wants to apply for mutual recognition of the national eID systems,” she explained.The current link between the Belgian pensions register and the ETS comprises a summary of accrued first and second pillar pension rights.It covers target level two of FYP in Europe, comprising individual pension information as well as pension entitlements in the provider’s own format. Workers can also request information, which can be provided through conventional mail.The project leader said the ETS project is now working on the concept for the FYP website as well as its – non-profit – business model, including the holder organisation, its legal shape, governance and financing.
The RBA was expected to act on Thursday to slash the official cash rate to 0.25 per cent, just two weeks after cutting to 0.5 per cent. The measure was expected to be coincide with bond buying an unprecedented move as officials work to shore up the Australian economy in widespread coronavirus fallout.RBA Governor Philip Lowe is set to give a speech out of the Reserve Bank in Sydney at 4pm on Thursday.CBA senior economist Gareth Aird expected RBA to cut the cash to “the effective-lower-bound of 0.25 per cent on Thursday” and put in place bond-buying and other measures to make borrowing cheaper. More from newsCOVID-19 renovation boom: How much Aussies are spending to give their houses a facelift during the pandemic3 days agoWhizzkid buys almost one property a month during COVID-197 days agoVideo Player is loading.Play VideoPlayNext playlist itemMuteCurrent Time 0:00/Duration 0:58Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -0:58 Playback Rate1xChaptersChaptersDescriptionsdescriptions off, selectedCaptionscaptions settings, opens captions settings dialogcaptions off, selectedQuality Levels720p720pHD432p432p216p216p180p180pAutoA, selectedAudio Tracken (Main), selectedFullscreenThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.This is a modal window. This modal can be closed by pressing the Escape key or activating the close button.Close Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button.PlayMuteCurrent Time 0:00/Duration 0:00Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -0:00 Playback Rate1xFullscreenHow much do I need to retire?00:58 MORE: Coronavirus won’t impact housing prices Philip Lowe, Governor of the RBA, is expected to announce a second March rate cut this week.Mortgages and borrowing will be the cheapest in Australian history with the Reserve Bank to take the unprecedented step of cutting interest rates twice in a month to a rock bottom 0.25 per cent. According to RateCity.com.au analysis the average mortgage holder with a $400,000 loan could save as much as $55 a month off minimum monthly mortgage repayments if there was a cut to 0.25 per cent cut passed on by lenders.RateCity.com.au research director Sally Tindall said many Aussies were ahead on their mortgages because banks kept their repayments the same when interest rates were cut.“This is money some people can potentially access through their redraw, should they find themselves in a tight financial position,” she said. “If interest rates are cut again, some mortgage holders may want to rethink what they do with the savings.” FOLLOW SOPHIE FOSTER ON TWITTER Renovation show postponed after COVID-19 concerns
51 Views no discussions LocalNews Joachim crowned Miss Plus Size and Elegance by: – February 13, 2012 Share Sharing is caring! Share Tweet Share Tamayo Joachim of Mero winner of the first ever Miss Plus Size and Elegant Tamayo Joachim of Mero has been crowned as the Miss Plus Size and Elegance for 2012.Joachim won the awards for Miss Intelligent, Best swim wear, Best evening wear, Best in creativity wear and Best evening wear at the Krazy Kokonuts onSaturday evening.Corinthia Felix of Mahaut placed first, Mary Raffoul placed second, while Claudine Charles placed third.The awards for Best talent and Miss Amity went to Mary Raffoul, the award for best Creative wear went to Corinthia Felix and Best in swimwear award went to Claudire Charles.The other contestants who participated in the competition were Druceila Moreau of Roseau, Felicia Jean-Marie of Colihaut and Kellisa Pascal of Calihaut.Photographs by Lyc’elle Registe of the competition: [nggallery id=140]Dominica Vibes News
Share LocalNews Three communities to benefit from Bense water supply project by: – July 9, 2012 Tweet Sharing is caring! Share Share 8 Views no discussions The communities and residents of Anse-de-Mai, Bense and Hamstead are set to benefit from a new water supply project which will cost the government of Dominica $2.9 million.An official ground breaking ceremony and signing of contracts will occur at the Bense Primary School today, July 9th, 2012.According to DOWASCO’s public relations officer, Edward Registe, a new intake and treatment facility will be built along the Hampstead River as well as a new storage tank and the adjoining pipe works. Upon completion of the project, the new water supply system is expected to meet the growing demands of the expanding community. It has been divided into two lots; lot one will involve “the construction of the new intake and access route as well as the pipe works while lot two will involve the construction of the storage tank and chlorinator house”.The contracts for the undertaking of each lot have been awarded to two local construction companies. Prime Minister Roosevelt Skerrit, Minister responsible for Water Resource Management, Reginald Austrie, and Parliamentary Representative for the Paix Bouche constituency, Mathew Walter along with DOWASCO officials are expected to address the function which is scheduled to commence at 4pm. Dominica Vibes News