Lucknow: Bahujan Samaj Party (BSP) supremo Mayawati Thursday expressed concern over the high unemployment rate in the country. In a statement issued here, she said, “The Union Labour Ministry, in its data released after the Lok Sabha election, has confirmed that joblessness in the country was 6.1 per cent of total labour force, highest in the last 45 years. For the victims of poverty and unemployment, there is no point of regretting now.” She also said the dip in growth rate “is result of fall in agricultural and industrial output”. Also Read – Pak activated 20 terror camps & 20 launch pads along LoC”The point of concern is that how true welfare will be done for the poor people of the country,” Mayawati said. On May 31, the government confirmed the unemployment rate projected in a pre-election leaked report and said joblessness in the country was 6.1 per cent of total labour force during 2017-18, the highest in 45 years. The data released by the Labour Ministry on a day when Modi 2.0 Cabinet took charge, showed 7.8 per cent of all employable urban youths being jobless, while the percentage for the rural was 5.3 per cent. The joblessness among male on all India basis was 6.2 per cent, while it was 5.7 per cent in case of females. India’s economic growth rate slowed to a five-year low of 5.8 per cent in January-March 2018-19 due to poor performance in agriculture and manufacturing sectors, according to official data.
New Delhi: The Indian team management are “not confused” about the composition of the World Cup squad despite their ODI series defeat against Australia as only one slot is up for grabs, said skipper Virat Kohli. Before the start of the series, Kohli had said that a couple of places need to be sealed and now it is down to just one man. While the confusion regarding No 4 slot and second wicketkeeper’s position remain, the skipper said that they are “sorted”. Also Read – Dhoni, Paes spotted playing football together”We are more or less sorted,” Kohli said at the post-match presentation ceremony adding: “Now, it’s about giving guys their roles and expect them to stand up. We are not at all confused. Maybe there’s just one spot we’ve to discuss.” Kohli said that giving fringe players game time was always an idea and he will not use it as an excuse for not winning the series. “Last three games, the idea was to give fringe guys some (game) time and see how they react. No excuses, we’re expected to raise our standard of cricket. The changes will never be an excuse. We will (still) take a lot of confidence going into the World Cup,” the skipper said. Kohli expects that his players will reflect on the mistakes made during the series and take corrective measures going into the World Cup. Also Read – Andy Murray to make Grand Slam return at Australian Open”It’s good we have had these losses, to correct these at the World Cup. The guys will reflect on this series quite a bit. We have been playing a lot of games on the road. We can be proud of the cricket that we’ve played in the last few months. The series didn’t go well yes, but we’ve played well,” the skipper was all praise for his team. On the series defeat, Kohli was magnanimous in his praise for the Australian side which had “more hunger”.
A robber fooled a woman on Thursday in Nabi Karim and allegedly stole her bag from an open window of a car while she and her friend were distracted by his accomplice. The concerned police station has registered an FIR in the case. The complainant, who had arrived in Delhi from Mauritius on business, was sitting in the passenger seat of her friend’s car and had stopped at a restaurant on Deshbandhu Gupta Road. While her friend was talking to the restaurant owner, the victim alleged that a man walked up to the car and picked up Rs 220 from the street, claiming it was hers. Also Read – After eight years, businessman arrested for kidnap & murder The robber made a run for it as the complainant’s friend was coming back. In the hubbub that followed, an accomplice simply snatched the victim’s bag, which was kept on the back seat of the car, from an open window and dashed. The bag contained Rs 18,000 in cash, the woman’s passport, visa, smartphone, ATM card, and other important documents. This is the second such robbery in Deshbandhu Gupta Road within the last five days. On April 1, three robbers used the same modus operandi to fool a car driver and dash with the owner’s bag which contained Rs 50 lakh in cash and other important documents. This case was also registered at the Nabi Karim police station. Both the robberies took place within 100m of each other on the same stretch of DBG road, according to details in the FIRs accessed by Millennium Post. Police said that they are investigating all possible angles in the aforementioned robberies. They added that they have not ruled out the possibility of the crime being committed by the same group of robbers.
NEW YORK — Intel is changing Robert Swan’s status as interim CEO, to permanent.Swan, 58, has led the chipmaker since June, when CEO Brian Krzanich resigned after the company learned that he had carried on a consensual relationship with an employee. The relationship violated Intel’s non-fraternization policy, which applies to all managers.Swan had been the company’s chief financial since 2016 and becomes somewhat of a rarity as CEO of Intel: an outsider. Krzanich had been CEO for five years, and joined Intel Corp. in 1982 as an engineer.Swan had previously worked at General Atlantic LLC, a private equity firm.Swan takes over during a tricky period for Intel Inc. The Santa Clara, California, company recently cut its outlook amid rising trade tensions and a slowing global economy.The Associated Press
Rabat – French newspaper Le Point has hailed Morocco as a world power in the making, drawing attention to the list of social and economic changes the North African country has witnessed of late.The paper’s almost eulogistic coverage commends Morocco socio-economic transformations, detailed in a July 11 editorial headlined “Morocco, the New Power.” The article draws a fine portrait of an already established continental or regional giant consistently flexing its muscles to make a full-throated entrance into the court of a much more respected kind of giants: world powers.Morocco, Le Point argues, has changed for the better. And, while there are still some loopholes in the North African country’s grand design,—there is always room for improvement—the magnitude of the change and the apparent existence of the political will to move things forward make Morocco’s case more forceful to international observers. “Morocco,” the editorial puts it bluntly, is “a new power.” To give a sense of why the north African country deserves this litany of compliments, the article went on to cite a flurry of international reports from acute observers, from the IMF to the World Bank. When it comes to the health of the Moroccan economy, and the promises of its market, most reports agree that the kingdom is a good place to invest, Le Point emphasized.Part of the Moroccan success story has to do with an “enlightened royal vision,” “good policy choices,” a functioning multipartism, increased visibility for Moroccan women, and an increasingly robust institutional framework to meet the challenges the kingdom has set for itself in its new development plan.‘Blossoming’ MoroccoBut there is also the construction of hypermodern infrastructure mushrooming in cities across the country. Such strikingly “modern” infrastructure, the editorial reminds its readership, include the newly completed Tangier Med Port and the equally newly built high speed train line now connecting Tangier and Casablanca. “Here blossoms what tomorrow’s Morocco will look like,” the article says of the “audacious” urbanization projects gradually taking shape in numerous Moroccan cities.The strength of this assertive and constantly changing Morocco resides in its qualified and country-loving human resources, Neila Tazi, a leading businesswoman and member of Morocco’s General Confederation of Enterprises (CGEM), told the French newspaper. “We may not have oil, but our real strength is found in human and geographical capital,” the businesswoman said.Towards the end of its celebratory portrait of Morocco, Le Point acknowledged that, of course, all is not a bed of roses in the emerging, assertive Morocco. Some “fragile” points remain and need tackling. Those have to do with a stuttering public education system, “persisting social inequalities,” an insufficient application of gender equality laws, as well as a poignant “brain drain” as a number of highly qualified Moroccans elect to emigrate for better opportunities and treatment.Read Also: In Pictures: Morocco’s TGV, Africa’s First High Speed TrainDespite these persisting “fragilities,” Le Point stressed, Morocco’s openness to global free trade, its rapid industrialization, its expanding network of modern infrastructure, as well as the existence of a genuine political will suggest that “tomorrow’s Morocco” will be an even more important actor in global dealings.Le Point may have given little space to the challenges still holding Morocco back to make its overreaching case of Morocco becoming an indispensable player on the world stage. But the French magazine is hardly the first to shower Morocco with approving nods. Over the past three to five years, Morocco has collected applause for, among other things, its growing assertiveness in Africa, its liberal-minded reforms, and its improving migration policy (even if some latest reports have indicated grey areas in terms of Morocco’s treatment of its expanding migrant populations.)Writing in February of last year, Ozy Media dubbed Morocco “the new emerging African power.” Since it joined the African Union, Ozy remarked, the North African country has been “riding on a combination of politics, economics and religion” to influence African politics “at a time when there’s a regional vacuum to be filled.”
Said Djinnit, the Secretary-General’s Special Representative for West Africa, met Alpha Condé in Conakry, the capital, where he reiterated the UN’s support to the democratic process in Guinea, which has suffered from decades of one-party rule or military regimes.Mr. Condé escaped unharmed from Tuesday’s attack, which Mr. Djinnit condemned, echoing similar remarks earlier this week from Secretary-General Ban Ki-moon and from the UN Peacebuilding Commission.He stressed the need for the President to pursue dialogue with all political parties, particularly in seeking a consensus over outstanding issues regarding the preparation of repeatedly delayed legislative elections, now slated to be held before the end of this year.Mr. Condé took office after winning the run-off round of presidential elections late last year, capping off the interim Government’s efforts to restore democracy after a 2008 coup d’état. 21 July 2011A senior United Nations envoy today called on the President of Guinea to pursue dialogue with opposition political parties in the troubled West African nation in the wake of the unsuccessful attack on his residence on Tuesday.
At a ceremony in Montego Bay, Jamaica, the three-year-old PanCaribbean Partnership against HIV/AIDS (PANCAP), chaired by Prime Minister Denzil Douglas of St. Kitts and Nevis, was praised for successfully mobilizing political backing and funds, raising the region’s international profile and coordinating the work of the 70 institutions in its membership.“Because of PANCAP’s work, we are one step closer to mitigating the social and economic impact of AIDS in the region,” UNAIDS Executive Director Dr. Peter Piot said. “PANCAP is a model of a successful regional approach which can be a stimulus and a source of lessons learned for other regions,” he added.In the Bahamas and Barbados the prevalence rates have edged down.At the ceremony, chaired by the UN Secretary-General’s Special Envoy to the Caribbean on HIV/AIDS, Sir George Alleyne, UNAIDS and the Caribbean Community (CARICOM) also launched a joint study of PANCAPS called “Common Goals, Shared Response.” Prime Ministers Owen Arthur of Barbados and Ralph Gonsalves of St. Vincent and the Grenadines addressed the crowd.Of the 49 million people living with AIDS worldwide, 440,000 are in the Caribbean and of those an estimated 280,000 are in Haiti. The Caribbean countries that are most dependent on tourism have been the most affected, according to the UNAIDS updated report on the region for December 2004. The report says, “Social, not just technical, challenges will need to be confronted if the countries of this region are to bring their epidemics under control. “Widespread homophobia is providing an ideal climate for the spread of HIV by driving men who have sex with men further away from the information, services, and security they need if they are to protect themselves against HIV. Meanwhile, the unequal social and economic status of women and men is acting as a powerful dynamic in epidemics that are growing amid ongoing stigma, misconceptions and denial.”
Confirmation of the use of chemical weapons in Syria two years ago served as “a shocking reminder” that their use has not yet been consigned to history said the Secretary-General in a message delivered on his behalf by Virginia Gamba, Deputy to the UN High Representative for Disarmament Affairs, at a ceremony in Ypres, Belgium, where the first chemical attack was recorded 100 years ago today.“The only fitting tribute to the memory of those who died at Ypres, and to all victims of chemical warfare, is to rid the world of chemical weapons once and for all,” Mr. Ban said in a message delivered by Ms. Gamba at an event held at the site of the Second Battle of Ypres.“The horrors of the First World War must be recalled as we grapple with today’s security challenges,” he said. “On this solemn anniversary, we remember the atrocities with the resolve to make sure that unlike that gas, the threats do not linger.”The UN chief recalled that the first time that chemical weapons had been deployed on a large scale in battle helped prompt the 1925 Geneva Protocol, which banned the use of chemical weapons outright. And some 70 years later, the Chemical Weapons Convention prohibited the development, production, acquisition, stockpiling, retention, transfer and use of chemical weapons, and it also required States Parties to destroy any chemical weapons they owned or possessed.“The Geneva Protocol and the Chemical Weapons Convention are accepted as an indispensable part of the international norm against chemical weapons,” Mr. Ban said.He also praised the multinational effort to eliminate the chemical weapons programme of Syria “as a momentous undertaking and an important achievement” that “reaffirmed international resolve against chemical weapons, and it illustrated the power of collective action in the service of a common goal.”But at the same time, he said: “We owe it to the victims of chemical weapons over the past 100 years – and future generations at risk of attacks – to remember that the world is not free from this threat.”Noting that “allegations of the use of chemical weapons continue,” Mr. Ban said that “some of these allegations surround the use of chlorine gas is a bitter irony and a reminder that the international community cannot be complacent about its achievements, nor can it allow the taboo that surrounds such weapons to fade.”Chlorine gas was used at Ypres on April 21, 1915, and is reportedly the same type of gas used in Syria.The Organization for the Prohibition of Chemical Weapon (OPCW) marked the Centennial Commemoration of the first large-scale use of chemical weapons at Ypres and honoured the memory of and paid tribute to all victims of chemical weapons.According to OPCW, chemical weapons resulted in more than one million casualties, and nearly 100,000 deaths during the First World War.
An armed robber made off with an undisclosed amount of cash from a bank in Anixi, a rural area north of Athens, after shooting through the window of the bank on Wednesday morning and threatening the manager and teller at gunpoint.No one was injured when he fired the shot as there were no customers in the bank at that time.Source: Kathimerini Facebook Twitter: @NeosKosmos Instagram
Leicester City manager Claude Puel has backed club captain Wes Morgan after he was sent off during the club’s disappointing 4-2 away defeat at Bournemouth.The Foxes will be without their skipper for next week’s visit of Huddersfield Town to the King Power Stadium, after his red card handed him a one-game ban but Puel has leapt to the defence of his captain.“He started the season well with good games and good intensity, good strength,” said Puel, according to Leicester Mercury.“He conceded the sending off but I felt it was harsh to concede the sending off today. I don’t have a problem with Wes.”“We had a problem with the concentration and focus, and we conceded two goals to the only moves from this team. We conceded from their first two moves. We have to correct this.”“We took the counter attack and created good chances for us, and they use this opportunity very well. We have to correct this for the future.”Liverpool legend Nicol slams Harry Maguire’s Man United form Andrew Smyth – September 14, 2019 Steve Nicol believes Harry Maguire has made some “horrendous mistakes” recently, and has failed to find his best form since joining Manchester United.Meanwhile, new signing Caglar Soyuncu might be ready to step in for the suspended Morgan, despite struggling with the U-23s on Sunday.“We have a solution of course,” said Puel.“We have good players with Jonny Evans and with Soyuncu, and we will see with calm next week.“It will be an opportunity for the players to show their quality and I am not afraid about this.“My concern is just this game will be an accident for the future. That is my last thought because we deserved other things from the beginning of the season.“It is a shame but we have responsibility, I am responsible, and together we will correct this.”
July 13, 2018 Posted: July 13, 2018 00:00 00:00 spaceplay / pause qunload | stop ffullscreenshift + ←→slower / faster ↑↓volume mmute ←→seek . seek to previous 12… 6 seek to 10%, 20% … 60% XColor SettingsAaAaAaAaTextBackgroundOpacity SettingsTextOpaqueSemi-TransparentBackgroundSemi-TransparentOpaqueTransparentFont SettingsSize||TypeSerif MonospaceSerifSans Serif MonospaceSans SerifCasualCursiveSmallCapsResetSave SettingsDEL MAR (KUSI) – Racing season is starting next week and the Del Mar Racetrack is going to be filled all summer long.Celebrity Chef Brian Malarkey was here to show us some of the delicious food being offered at the track and a special ticket option, Taste of the Turf Club.RELATED STORY: Del Mar’s Summer racing season is back “Where the Turf Meets the Surf”For more information, click here. Celebrity Chef Brian Malarkey previews the food at the Del Mar racetrack KUSI Newsroom KUSI Newsroom, Categories: Good Morning San Diego, Local San Diego News FacebookTwitter
Clark County economic development leaders said Thursday they’re working to make Boeing Co. a bigger presence in the region by recruiting its suppliers and by expanding existing -companies that help equip the aerospace giant.Lisa Nisenfeld, president and CEO of the Vancouver-based Columbia River Economic Development Council, said a task force has been formed to spearhead the effort.Area leaders are working with the city of Gresham, Ore. — where Boeing has a parts facility — along with Cowlitz County and Greater Portland Inc., a private sector-led business promoter of the Portland-Vancouver area, she said.With Boeing planning for significant growth, Nisenfeld said, “we think there’s enough for -everybody here.”Nisenfeld delivered her remarks during a luncheon held by the Camas-Washougal Chamber of Commerce and attended by more than 60 people. She was joined by Paul Dennis, former mayor of Camas and now president and CEO of the Camas-Washougal Economic Development Association, who talked about his efforts to grow the economy in east Clark County.Regional leaders’ focus on -Boeing comes as the company makes plans to boost production in the Puget Sound region, and as Boeing executives have publicly acknowledged hiccups in the company’s global outsourcing network and their intentions to do more work in-house. Paul Dennis
Dear Editor,I want to thank all of the voters who supported me at last Saturday’s Town Election. I’m grateful for the many people worked very hard to make this possible. It was a total team effort. I would like to congratulate all of the other candidates who participated and those who were elected. I sincerely appreciate all of the support I have received over the past few months. I look forward to working hard and volunteering my time to help the residents of our town. My hope is that we can all work together to keep Wilmington moving forward in a positive direction.Thank you,Greg BendelLike Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email firstname.lastname@example.org.Share this:TwitterFacebookLike this:Like Loading… RelatedLETTER TO THE EDITOR: Bendel Thanks The VotersIn “Letter To The Editor”LETTER TO THE EDITOR: Selectman Kevin Caira Thanks The VotersIn “Letter To The Editor”A VOTER’S GUIDE To Selectman Candidate Greg BendelIn “Government”
Rakshit Shetty in action in GermanyKarnataka’s sporting culture has bred many successful athletes and sportspersons. One boy who is starting to make a big splash in the sport of shooting is Rakshit Shastry. The 27-year old from Mysuru has been climbing the ladder of success and his latest triumph came in Germany where he won, with two of his teammates, a silver for the country in the International Shooting Competition of Hannover (ISCH), some weeks ago.This is only the latest triumph of the young man who has been steadily establishing himself in the community of Indian shooting. Shastry has been lucky to get the guidance of good coaches and support of other people to reach this level.The main coach for the Mysuru lad has been ex-armyman Suresh MS, himself a decorated shooter in the past and a former national record holder. With over 35 medals at national events, Suresh was the best person to help Shastry reach greater heights of success. Rakshit, with his teammates, on the left of the podiumWhat is most impressive about the Mysuru lad’s performance is his rapid rise since venturing into the sport for the first time. It was only in 2015 that he first took lessons in shooting and after a 14-day period of training, went on to win a silver in state shooting championship.Then, qualifying for Karnataka ‘A’ team the same year, he won team gold in South Zone shooting championship. Competing at the national level in the All India GV Mavalankar Shooting Championship of 2016, he came 3rd. Overall, in his career, Shastry has claimed more than 50 medals at different levels.Speaking about his success, the young man credited those people who have extended help to him through monetary or other ways. “I have been supported by the organisation, my managers Mr Pranesh, Mr Harish Chandan and especially Arjun sir who motivates me to work better and perform better in sports as well,” he said.The success in Germany has now brought Rakshit onto the international stage. Hopefully, it will catapult him to greater levels of success and get him among the top shooters of the country.
A Myanmar Border Guard Police officer keeps watch near the Taung Pyo Letwe reception camp overlooking the border with Bangladesh, in Rakhine state, Myanmar, on 1 May 2018. Photo: ReutersArakan Rohingya Salvation Army (ARSA) on Friday categorically denied what it says “unjustifiable and careless serious criminal accusations” made by the Amnesty International.In a statement it said it is appalling to learn the recent report titled “New evidence reveals armed group massacred scores in Rakhine State” released by the Amnesty International as the report consists of serious criminal accusations against ARSA, reports UNB.“We categorically deny all of these unjustifiable and careless serious criminal accusations mentioned in the report,” it said.ARSA, however, expressed its gratitude and appreciation to the Amnesty International for its tremendous efforts in advocating human rights across the world.The AI in a report on Tuesday claimed that a Rohingya armed group brandishing guns and swords is responsible for at least one, and potentially a second, massacre of up to 99 Hindu women, men, and children as well as additional unlawful killings and abductions of Hindu villagers in August 2017.ARSA said it is illogical and unreasonable for any Rohingya to commit any crime against a Hindu who is not killing or attacking Rohingyas.It said they are ready, at all time, to cooperate with a credible international investigation mission or agency which has the full mandate to investigate as to whether these alleged crimes are done by ARSA.It said the “Burmese Terrorist Government” must allow the international investigation mission unconditional access to all the affected areas in Arakan State to conduct a detailed and systematic investigation if it is confident that its “terrorist Army” did not commit any of these crimes.
Register Now » 3 min read This story originally appeared on Reuters President Barack Obama’s executive action on immigration is expected to include some modest changes to make it easier for technology companies to retain high-skilled workers frustrated by long and unpredictable waits for green cards.But the major overhaul that the tech sector is seeking of the visa and green card system would require action by Congress. For now at least, the prospects for legislation appear to be slim.Obama has pledged take executive action on immigration by year-end and could act as early as next Friday. Lobbyists for tech companies said they have not seen details about the fixes. But based on the options the tech sector pitched to the administration, they are expecting only incremental changes.”We’d be grateful for anything, really, because the situation is that severe,” said Emily Lam, a vice president with the Silicon Valley Leadership Group, a trade group that represents more than 375 employers.”The true fix really has to be legislative, anything within their power is really going to be tweaking on the sides. It doesn’t solve the fundamental issues,” she said.One big reform that requires legislation: lifting the annual cap for H1B visas for specialized technology workers that last for up to six years.The United States loses about 500,000 jobs per year because of those limits, according to estimates from Compete America, a coalition representing tech giants including Amazon, Facebook and Microsoft.Most changes within Obama’s powers are aimed at easing the transition for workers moving from H1B visas to greencards.For example, lobbyists think the administration could finalize a regulation announced in May that would give work permits to spouses of some skilled immigrants with temporary visas.The most ambitious proposal for tech would speed up long wait lists for green cards for employees on temporary H1B visas by changing the way their spouses and children are counted under an annual cap of 140,000.But several lobbyists told Reuters they were not optimistic that the proposal would be accepted due to fears by some lawyers it could be challenged in court.”I think some of it will be band-aids,” said one industry lobbyist. “While they’re little fixes, it creates a bigger political problem,” the lobbyist said.The fear is that bigger legislative fixes for business could get caught up in an explosive political war between Republicans and Obama over relief for undocumented immigrants, prolonging the needed changes.(Reporting by Roberta Rampton; Editing by Bernard Orr) Free Webinar | Sept. 9: The Entrepreneur’s Playbook for Going Global Growing a business sometimes requires thinking outside the box. November 17, 2014
News | Magnetic Resonance Imaging (MRI) | May 17, 2017 MRI Offers New Insights Into Tumor Metabolism German study finds MRI with a new biosensor shows pH value changes Two brain metastases from primary lung cancer are contrast enhanced in the brain of a 61-year-old male. Speakers at AHRA 2019 will state that ProHance and other macrocyclic MR agents present a very low risk to patients. Images courtesy of Bracco Related Content News | Neuro Imaging | July 05, 2019 Delta T1 Maps Provide Quantitative, Automated Solution to Assess Brain Tumor Burden Imaging Biometrics LLC (IB) a subsidiary of IQ-AI Ltd., is highlighting a recently published study in the American… read more News | Focused Ultrasound Therapy | July 10, 2019 Insightec’s Exablate Neuro Approved With GE Signa Premier MRI in U.S. and Europe GE Healthcare and Insightec announced U.S. Food and Drug Administration (FDA) approval and CE mark for Insightec’s… read more Technology | Interventional Radiology | August 16, 2019 Profound Medical Receives U.S. FDA 510(k) Clearance for Tulsa-Pro Profound Medical Corp. announced it has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) to… read more News | Neuro Imaging | August 16, 2019 ADHD Medication May Affect Brain Development in Children A drug used to treat attention-deficit/hyperactivity disorder (ADHD) appears to affect development of the brain’s… read more News | Image Guided Radiation Therapy (IGRT) | July 16, 2019 AAPM 2019 Features More Than 40 Presentations on ViewRay’s MRIdian MRI-guided Radiotherapy ViewRay Inc. announced that the company’s MRIdian System is the focus of more than 40 abstracts selected by the… read more Feature | Contrast Media | July 18, 2019 | By Greg Freiherr How To Manage Risk in the MR Suite Macrocyclic contrast agents have the best safety profile of all the magnetic resonance (MR) contrast media that are n read more Images of regions of interest (colored lines) in the white matter skeleton representation. Data from left and right anterior thalamic radiation (ATR) were averaged. Image courtesy of C. Bouziane et al. News | Magnetic Resonance Imaging (MRI) | August 06, 2019 Canon Medical Introduces Encore Orian MR Upgrade Program Canon Medical Systems USA Inc. is helping to provide low-cost patient care solutions for its customers with the launch… read more Technology | Contrast Media | July 15, 2019 FDA Approves Bayer’s Gadavist Contrast for Cardiac MRI in Adult Coronary Artery Disease Patients The U.S. Food and Drug Administration (FDA) has approved Gadavist injection for use in cardiac magnetic resonance… read more May 17, 2017 — Tumors, inflammation and circulatory disorders locally disturb the body’s acid-base balance. These changes in pH value could be used for example to verify the success of cancer treatments. Up to now, however, there has been no imaging method to render such changes visible in patients. Now a team from the Technical University of Munich (TUM) has developed a pH sensor that renders pH values visible through magnetic resonance imaging (MRI) – in a non-invasive, radiation-free manner.Four years ago, during a magnetic resonance experiment with tumor cells, TUM physicist Franz Schilling, Ph.D., found signals from a molecule that was highly sensitive towards pH changes. The molecule, which was identified as zymonic acid in subsequent investigations, could play an important role in the future of medical imaging. As a biosensor for pH values, it could provide insights into the body which had been impossible in the past.”An appropriate pH imaging method would make it possible to visualize abnormal changes in tissue and specifically metabolic processes of tumors,” explained Schilling. Areas surrounding tumors and inflammations are usually slightly more acidic than areas surrounding healthy tissue, a phenomenon possibly linked to the aggressiveness of tumors. Schilling sees further potential uses in treatment prognoses. “pH values are also interesting when it comes to evaluating the efficacy of tumor treatments. Even before a successfully treated tumor starts to shrink, its metabolism and thus the pH value of the surrounding area could change. An appropriate pH imaging method would indicate at a much earlier stage whether or not the right approach has been selected,” he saidSchilling is now director of the working group for Preclinical Imaging and Medical Physics at the Clinic and Polyclinic for Nuclear Medicine in the TUM Klinikum rechts der Isar. In past years, he has joined together with colleagues from the departments of physics, chemistry and medicine to research zymonic acid as a biosensor. In the journal Nature Communications, the team describes how it can be used to reliably represent pH values in the bodies of small animals.In order to make pH values visible using zymonic acid, the molecule is injected into the body and then an MRI investigation is made of the object tissue. In a strong magnetic field, radiowaves excite the nuclear spins of the zymonic acid to oscillation. The reactions of the nuclei are then recorded. This data is used to calculate frequency spectra that in turn provide information about the chemical properties of the molecular surroundings of the nuclei. Ultimately, the pH value at any examined location in the tissue can be represented based on pH-dependent molecular changes in the zymonic acid.Zymonic acid has to be marked with carbon-13 in order to be visible in MRI images. This means that the molecules contain carbon-13 atoms (13C) instead of “normal” carbon 12 atoms. But zymonic acid marked in this manner is still not measurable; its MRI signal is too weak. “We therefore use a relatively new method, hyperpolarization,” explained Stephan Düwel, physicist and first author of the study. “We use a special device to transfer the polarization of electrons to the 13C atomic nuclei using microwaves at very low temperatures, which results in an MRI signal up to 100,000 times stronger.” A hot liquid is then used to quickly return the zymonic acid to room temperature.After this, the scientists need to act quickly. The biosensor is injected intravenously into the organism, then the MRI scan has to be made immediately: It only takes 60 seconds for the signal-amplifying effect of the hyperpolarization to wear off again. “We’re currently working on expanding this time window,” said Düwel.”On the one hand, we’re trying to improve the MRI properties of zymonic acid with appropriate modifications to the molecule; On the other hand, we’re looking for other pH-sensitive molecules,” explained biochemist Christian Hundshammer, second author of the study.Schilling and his team have succeeded in showing that their method is sensitive enough to represent medically relevant pH value changes in the organism. Using zymonic acid it is furthermore possible to specifically investigate the pH value outside of the cell membrane: With other biosensors it is often not clear whether measured changes take place inside or outside of the cell (intracellular or extracellular). This is important because the intracellular value is usually stable, while changes in metabolism have a much greater impact on the extracellular value.In contrast to optical methods, which are limited to superficial penetration into the body because of the low transparency of tissue, there are no limitations to the depth of penetration for MRI. It has furthermore been demonstrated that zymonic acid is not toxic in the concentrations used with small animals and is also created in low concentrations as a by-product of the metabolite pyruvic acid which is present in the body.”We believe zymonic acid is a highly promising biosensor for patient applications,” said Schilling. For the time being, however, additional pre-clinical studies are planned in order to ascertain the advantages of this new imaging biomarker compared to conventional methods and to further improve the spatial resolution of pH imaging.The research project was funded by the Collaborative Research Centre 824 (SFB824) “Imaging for Selection, Monitoring and Individualization of Cancer Therapies” led by Prof. Markus Schwaiger.For more information: www.nature.com/ncomms FacebookTwitterLinkedInPrint分享 News | Magnetic Resonance Imaging (MRI) | August 01, 2019 | Jeff Zagoudis, Associate Editor FDA Issues Draft Guidance on Medical Device Safety in MRI Environment The U.S. Food and Drug Administration (FDA) issued a new draft guidance titled Testing and Labeling Medical Devices for… read more Technology | Neuro Imaging | August 07, 2019 Synaptive Medical Launches Modus Plan With Automated Tractography Segmentation Synaptive Medical announced the U.S. launch and availability of Modus Plan featuring BrightMatter AutoSeg. This release… read more
Top Stories The Arizona Cardinals fell to the Los Angeles Chargers on Sunday, keeping them second in the 2019 NFL Draft order through Week 12.Arizona’s strength of schedule, which acts as a tiebreaker for teams with the same record, took a slight hit against the 8-3 Chargers. That and the San Francisco 49ers’ defeat at the hands of the Tampa Bay Buccaneers, which improved to San Francisco’s strength of schedule, moved the top two teams closer to one another than they were heading into the week. Across the rest of the bottom-rung of the NFL standings, the results in Week 12 made for seven teams who are within 2.0 games of the 2-9 Niners, Cardinals and Oakland Raiders.Those three teams, in that order, sit atop the NFL Draft order with five more weeks to play in the season.Related LinksCardinals have looming decision over Steve Wilks after loss to ChargersRapid Reaction: Cardinals again embarrassed in loss to ChargersChargers’ Philip Rivers sets NFL records against CardinalsIt’s time to start thinking about the Cardinals’ spot in the NFL DraftHere are a few rules about how the NFL Draft order is set:• The top of the draft order is decided by the inverse winning percentage of non-playoff teams.• Tiebreakers are based on inverse strength of schedule — the aggregate winning percentage of a team’s opponents. In other words, the team that played the weakest schedule with the worst combined record will earn a higher pick.Here’s a look at the top of the NFL Draft order after Week 12. PickTeamRecordStrength of schedule Grace expects Greinke trade to have emotional impact The 5: Takeaways from the Coyotes’ introduction of Alex Meruelo 10Tampa Bay Buccaneers4-7.528 (AP Photo/Mark Humphrey) 1San Francisco 49ers2-9.511 2 Comments Share 8Detroit Lions4-7.511 Former Cardinals kicker Phil Dawson retires 3Oakland Raiders2-9.557 Derrick Hall satisfied with D-backs’ buying and selling 9Buffalo Bills4-7.517 2Arizona Cardinals2-9.528 4New York Jets3-8.503 6Jacksonville Jaguars3-8.5387Atlanta Falcons4-7.509 5New York Giants3-8.511
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